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Welcome to the 20th European Neurofibromatosis Meeting Manchester UK a face to face conference. Whilst virtual conferences have led to a new way of working collaboratively internationally, these have somewhat stifled new collaborations as we have missed out on meeting socially together, as well as being able to talk face to face around posters. This is the 20th European Neurofibromatosis Conference representing over 30 years of NF conferences in Europe. The last conference was held in Rotterdam as a virtual conference in 2020 and previous conferences included the global Paris conference in 2018, the 2016 conference in Padua, 2014 in Barcelona with the 15th European NF meeting being held in Istanbul. This 2022 conference will be the second time that Manchester has hosted the European NF Conference. Manchester has a world-leading reputation in neurofibromatosis research and is one of just two highly specialised services for NF1 in England, as well as the lead centre for the four centres NF2 highly specialised service set up in 2010. NF research began in the late 1980s in Manchester with Manchester producing the first management consensus guidelines at Old Trafford in 2004. Manchester has a rich history of clinical, epidemiological and molecular research on NF1, NF2 and Schwannomatosis. We trust that the Manchester conference will be an opportunity to bring us all together again to foster new research collaborations and to update ourselves on the most advanced research on neurofibromatosis. We give you a warm welcome to Manchester.