Healthcare Events

Neurofibromatosis European Meeting – Manchester

Events for Healthcare

08:00 am
10 Oct, 2022 - 11 Oct, 2022
Mercure Manchester Piccadilly Hotel

Neurofibromatosis European Meeting – Manchester

Events for Healthcare

08:00 am
10 Oct, 2022 - 11 Oct, 2022
Mercure Manchester Piccadilly Hotel

Neurofibromatosis European Meeting - Manchester

Abstract Submissions for this Conference are now closed.

 

20th Neurofibromatosis Meeting Manchester 10-11 October 2022

The 20th European Neurofibromatosis Meeting will be held in Manchester UK in October 2022 as a face to face conference. Whilst virtual conferences have led to a new way of working collaboratively internationally, these have somewhat stifled new collaborations as we have missed out on meeting socially together, as well as being able to talk face to face around posters. The Manchester conference will be organised as a face to face conference, however, if the pandemic continues to challenge us we will convert to a hybrid conference enabling those who are not ready for face to face meetings to have access to the full programme. This will be the 20th European Neurofibromatosis Conference representing over 30 years of NF conferences in Europe. The last conference was held in Rotterdam as a virtual conference in 2020 and previous conferences included the global Paris conference in 2018, the 2016 conference in Padua,2014 in Barcelona with the 15th European NF meeting being held in Istanbul. This 2022 conference will be the second time that Manchester has hosted the European NF Conference. Manchester has a world-leading reputation in neurofibromatosis research and is one of just two highly specialised services for NF1 in England, as well as the lead centre for the four centres NF2 highly specialised service set up in 2010. NF research began in the late 1980s in Manchester with Manchester producing the first management consensus guidelines at Old Trafford in 2004. Manchester has a rich history of clinical, epidemiological and molecular research on NF1, NF2 and Schwannomatosis. We trust that the Manchester conference will be an opportunity to bring us all together again to foster new research collaborations and to update ourselves on the most advanced research on neurofibromatosis. We look forward to welcoming you to Manchester.

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Neurofibromatosis European Meeting – Manchester

Organising Committee:

Dr. Grace Vassallo
Consultant Paediatric Neurologist and Clinical Lead HSS Complex NF1 Service, Manchester University NHS Foundation Trust

Prof. Gareth Evans
Professor in Medical genetics and Cancer Epidemiology, University of Manchester, UK

Mrs. Judith Eelloo
Lead Nurse HSS Complex NF1 Service, Manchester University NHS Foundation Trust

Scientific Committee:

Prof. Gareth Evans
Professor in Medical genetics and Cancer Epidemiology, University of Manchester, UK

Prof Ian Kamaly
Professor in Paediatric Neurosurgery Manchester University Hospitals NHS Foundation Trust

Dr. Shruti Garg
Consultant in Child and Adolescent Psychiatry and Clinical Research Fellow at the Institute of Brain, Behaviour and Mental Health, University of Manchester, UK

Prof. Stavros Stivaros
Professor Paediatric Neuroradiology and Translational Imaging. University of Manchester.

Dr. Emma Burkitt-Wright
Consultant Clinical Geneticist St. Mary Genomic Centre for Medicine Manchester University Hospitals

Prof  Michel Kalamarides
Professor and Director of Neurosurgery at Pitie-Salpetrire Hospital

Prof Scott Plotkin
Harvard Professor of Neurology

Prof R Ferner
Professor of Neurology Guy`s and St. Thomas` Foundation Trust and National Lead for the HSS Complex NF1 service in UK

Prof Marco Giovannini
Department of Head and Neck Surgery - David Geffen School of Medicine at University of California Los Angeles

Prof Eric Legius
Human Genetics at the University of Leuven Belgium

Prof Juha Petonen
Cancer Research Unit and institute of Biomedicine University of Turku Finland

Prof Ignacio Blanco
Professor Germans Trias Hospital Barcelona Spain

Prof Pierre Wolkenstein
Professor of Dermatology and Head of the Department of Dermatology Hopital Henri-Mondor, Paris, France

Prof J P Kilday 
Professor of Neuroncology - Royal Manchester Children`s Hospital

Dr. R. Oostenbrink
General Paediatrician Erasmus MC Rotterdam

Dr. Eva Trevisson
Geneticist University of Padova Italy

Speakers

David Geffen

University of California Los Angeles

Dr Grace Vassallo

Manchester University NHS Foundation Trust

Consultant Paediatric Neurologist and Clinical Lead HSS Complex NF1 Service

Dr. Shruti Garg

The Institute of Brain, Behaviour and Mental Health, University of Manchester, UK

Consultant in Child and Adolescent Psychiatry and Clinical Research Fellow

Prof Michel Kalamarides

Pitie-Salpetrire Hospital

Professor and Director of Neurosurgery

Prof Eric Legius

University of Leuven Belgium

Professor of Human Genetics

Prof Gareth Evans

University of Manchester UK

Professor in Medical Genetics and Cancer Epidemiology Clinical Lead Manchester HSS NF2 Service

Prof Juha Petonen

University of Turka Finland

Cancer Research Unit and institute of Biomedicine

Prof Marco Giovannini

University of California Los Angeles

Professor of Neck and Head Surgery

Prof Rosalie Ferner

Guy's and St Thomas' Foundation Trust and HSS Complex NF1 Service in the UK

Professor of Neurology/National Lead

Prof Scott Plotkin

Harvard

Professor of Neurobiology

Prof Stavros Stivaros

University of Manchester UK

Professor Paediatric Neuroradiology and Translational Imaging

Prof. Andy King

Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Manchester Co-Director, Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre Northern Care Alliance NHS Group, University

Professor of Neurosurgery

Sponsors & Partners

The programme

08:00

Registration, Networking & Breakfast- Poster viewing opportunity

Registration, Networking & Breakfast Poster viewing opportunity

09:15

Introduction and Chairs Morning Session

Dr Grace Vassallo
Consultant Paediatric Neurologist and Clinical Lead HSS Complex NF1 Service
Manchester University NHS Foundation Trust
Prof. Andy King
Professor of Neurosurgery
Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Manchester Co-Director, Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre Northern Care Alliance NHS Group, University

Introduction and Chairs Morning Session

09:30

Keynote Lecture: 32 Years as an NF-ologist

Prof Gareth Evans
Professor in Medical Genetics and Cancer Epidemiology Clinical Lead Manchester HSS NF2 Service
University of Manchester UK
Keynote Lecture: 32 Years as an NF-ologist

09:50

History of NF in the UK

Dr. Sue Huson Clinical Geneticist & Meena Upadhyaya Distinguished Professor ( Hon) Division of Cancer and Genetics Cardiff University

10:00

A Phase I Study to Assess the Effect of Food on the Gastrointestinal (GI) Adverse Events (AEs) and Pharmacokinetics (PK) of Selumetinib in Adolescents with Neurofibromatosis Type 1 (NF1) Related Plexiform Neurofibromas (PN)

Prof David Viskochil-Department of Paediatrics, University of Utah, Salt, Lake City, Utah, USA

10:10

Clinical characteristics and management of patients with neurofibromatosis 1 and plexiform neurofibromas in Denmark: A nationwide study

Dr. Cecilie Ejerskov, Centre for Rare Diseases, Aarhus University Hospital, Denmark

10:20

Risk Factors in Pediatric Malignant Peripheral Nerve Sheath Tumours (MPNST): Results from the French Pediatric Oncology Society (SFCE) cohort.

Dr Jordane Chaix – Paediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Paris , France

10:30

Questions from Oral Presentations

Questions from Oral Presentations

10:40

Platform trials as an opportunity to identify new treatments in NF: identifying potential participating centres

Panel: Rianne Oostenbrink (chair) 1, Britt Dhaenens1, Jonas Leubner2, Eric Legius3

1 ErasmusMC- Sophia's Children's Hospital, Rotterdam, The Netherlands.
2 Charité-Universitätsmedizin Berlin, Berlin, Germany
3 Katholic University Leuven, Belgium

11:30

Challenges in NF2 novel therapy research, patient non-profit perspective.

Gilles Atlan
Vice President
NF2 BioSolutions UK & Europe
  • Challenges in NF2 novel therapy research, a patient non-profit perspective. 4 years of updates, challenges and innovation by NF2 BioSolutions. Gilles Atlan - Vice President NF2 BioSolutions
  • Sporadic and NF2 Schwannomatosis Vestibular Schannomas Share Homogeneous Tumour Microenvironments- Grace Gregory, PhD Student (NF2 Biosolutions), University of Manchester
  • High dimensional imaging highlights the T-cell compartment as a viable therapeutic target in the vestibular schwannoma tumour microenvironment- Adam Paul Jones, PhD Student ( NF2 Biosolutions ), University of Manchester

12:15

POPLAR-NF2: A Parallel-group, Two-staged, Phase 2/3, Randomized, Multicenter Study to Evaluate the Efficacy and Safety of REC-2282 in Participants with Progressive NF2 Mutated Meningiomas

Glenn Morrison, Recurison Pharmaceutical Inc

12:30

Lunch and Networking Break. Poster Viewing and Special Interest Breakout Sessions

  • Lunch and Networking Break - Poster viewing opportunity
  • Special interest breakout sessions with lunch
  • Breakout session room 1 NF1 Neuromuscular Special Interest Group- Lead Dr. Amish Chinnoy Is NF1 muscle weakness due to neurological ('central') or muscular ('peripheral') pathology? With Contributions from Dr. Siobhan West Consultant Paediatric Neurologist for the complex NF1 service and Prof. Ir. Hans Degens, Professor of Muscle Physiology, Visiting Professor, Lithuanian Sports University, Kaunas Department of Life Sciences Research Centre for Musculoskeletal Science & Sports Medicine Manchester Metropolitan University
  • Breakout session room 2 NF2/ Schwannomatosis Special Interest Group- Lead Prof Gareth Evans What do we still need for NF2/Schwannomatosis? Invited Speaker-Cristina Perez-Becerril- Research Associate, University of Manchester - Improving sensitivity for detection of pathogenic variants in familial NF2-related schwannomatosis

13:30

Chair afternoon: Prof G. Evans

Prof Gareth Evans
Professor in Medical Genetics and Cancer Epidemiology Clinical Lead Manchester HSS NF2 Service
University of Manchester UK
Chair afternoon: Prof G. Evans

13:30

Keynote Lecture: SPRED 1

Prof Eric Legius
Professor of Human Genetics
University of Leuven Belgium

Keynote Lecture: SPRED 1

14:00

Molecular Diagnosis of Mosaic Disease in the NF1 clinic

Dr. Emma Burkitt-Wright Consultant Clinical Geneticist HSS Complex NF1 service Manchester, Manchester University Hospital NHS Foundation Trust

14:10

Creation of the international NF Variant Curation Expert Panel to improve genetic testing of NF-SCHW genes

Elisabeth Castellanos, Clinical Genomics Research Group, Germans Trias & Pujol Research Institute (IGTP); Genetics Service, Clinical Laboratory North Metropolitan (LCMN), Germans Trias & Pujol University Hospital (HUGTiP), Can Ruti Campus, Badalona, Barcelona, Spain

14:20

Questions from Presentations

Questions from Presentations

14:25

Phase 2a randomized, double blind, vehicle-controlled trial of NFX-179 Gel in Persons with Neurofibromatosis Type 1 with cutaneous neurofibromas.

Gerd Kochendoerfer, PhD

NFlection Therapueutics

14:40

How we image NF1

Dr. Calvin Soh Consultant Neuroradiologist HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust

14:50

Diagnostic and classification challenges of NF1-related gliomas

  • Ms Tina Karabatsou Consultant Neurosurgeon HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust and Northern Care Alliance NHS Foundation Trust and Professor Federico Roncaroli Professor of Neuropathology Northern Care Alliance NHS Foundation Trust and The University of Manchester

15:10

Questions from Case Presentations

  • How we image NF1 Dr. Calvin Soh Consultant Neuroradiologist HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust
  • Diagnostic and classification challenges of NF1-related gliomas Ms Tina Karabatsou Consultant Neurosurgeon HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust and Northern Care Alliance NHS Foundation Trust and Professor Federico Roncaroli Professor of Neuropathology Northern Care Alliance NHS Foundation Trust and The University of Manchester

15:20

Networking, Coffee Break and Poster Viewing Opportunity

Networking, Coffee Break and Poster Viewing Opportunity

15:40

Chairs- Dr Shruti Garg and Dr Emma Burkitt- Wright

Dr Shruti Garg – Consultant in Child and Adolescent Psychiatry, Manchester University NHS Foundation Trust and  Clinical Research Fellow The Institute of Brain, Behaviour and Mental Health, University of Manchester  

Dr Emma Burkitt-Wright,  Consultant Clinical Geneticist HSS Complex NF1 service Manchester, Manchester University Hospital NHS Foundation Trust

15:40

Keynote Presentation: Epidemiology of NF1 and NF2 in Finland

Prof Juha Petonen
Cancer Research Unit and institute of Biomedicine
University of Turka Finland

Keynote Presentation: Epidemiology of NF1 and NF2 in Finland

16:10

Prevention of neurological signs and symptoms in children with NF1 and Brain stem gliomas-When is too little too late?

  • Dr. Grace Vassallo, Consultant Paediatric Neurologist and Clinical Lead HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust
  • Dr Emily Wilkins, Paediatric Trainee North West Deanery

16:20

Generic Health-Related Quality of Life: Analysis of the Pediatric Quality of Life Inventory and Child Health Questionnaire in children with Neurofibromatosis Type 1

  • Dr Britt Dhaenens, Department of General Paediatrics, ErasmusMC-Sophia’s Children’s Hospital, Rotterdam, The Netherlands
  • 16:30

    The course of intellectual development in children with Neurofibromatosis Type 1 based on longitudinal history study

  • A.M. (Sandra) van Abeelen, Kempenhaeghe, Center for Neurological Learning Disabilities, Netherlands
  • 16:40

    Questions from Oral Presentations

    Questions from Oral Presentations

    Prevention of neurological signs and symptoms in children with NF1 and Brain stem gliomas-When is too little too late?

    Dr. Grace Vassallo, Consultant Paediatric Neurologist and Clinical Lead HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust

    Generic Health-Related Quality of Life: Analysis of the Pediatric Quality of Life Inventory and Child Health Questionnaire in children with Neurofibromatosis Type 1

    Dr Britt Dhaenens, Department of General Paediatrics, ErasmusMC-Sophia’s Children’s Hospital, Rotterdam, The Netherlands

    The course of intellectual development in children with Neurofibromatosis Type 1 based on longitudinal history study

    A.M. (Sandra)  van Abeelen, Kempenhaeghe, Center for Neurological Learning Disabilities, Netherlands

    16:50

    Opportunities from CTF Europe

    Marco Nievo PhD, Chief Scientific Officer CTF Europe.

    17:00

    Chairs: Dr. Grace Vassallo and Prof Ian Kamaly-Asl

    Dr Grace Vassallo Consultant Paediatric Neurologist and Clinical Lead HSS Complex NF1 Service

    Manchester University NHS Foundation Trust

     

    Professor Ian Kamaly-Asl

    Professor of Paediatric Neurosurgery, Manchester University NHS Foundation Trust and University of Manchester

    17:00

    Keynote Lecture: Key neuroradiological features in Paediatric NF1 and NF2

    Prof Stavros Stivaros
    Professor Paediatric Neuroradiology and Translational Imaging
    University of Manchester UK
    Keynote Lecture: Key neuroradiological features in Paediatric NF1 and NF2

    17:30

    Close of Event Day 1

    Close of Event Day 1

    19:00

    Conference Meal, Awards and Entertainment

    Conference Meal, Awards and Band Entertainment

    08:00

    Registration & Breakfast - Networking & Poster viewing

    Registration & Breakfast - Networking & Poster viewing

    08:00

    Symposium: Call for an international consortium for the validation of the cNFSkindex questionnaire and other patient reported outcome measures in NF

  • Laura Fertitta1 and Britt Dhaenens2, Rianne Oostenbrink2, Pierre Wolkenstein1 1 Department of Dermatology, National Referral Center for Neurofibromatoses, Henri Mondor Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Créteil, France. 2 Department of General Paediatrics, Erasmus MC- Sophia's Children's Hospital, Rotterdam, The Netherlands.
  • 09:00

    Chairs: Dr Alexander Lee and Prof Ian Kamaly Asl

    Dr Alexander Lee, Consultant Medical Oncologist, The Christie NHS Foundation Trust and HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust

    Professor Ian Kamaly-Asl, Professor of Paediatric Neurosurgery, Manchester University NHS Foundation Trust and University of Manchester

    09:00

    Keynote Lecture: MPNST

    Prof Rosalie Ferner
    Professor of Neurology/National Lead
    Guy's and St Thomas' Foundation Trust and HSS Complex NF1 Service in the UK
    MPNST

    09:30

    Therapeutics discovery using synthetic lethal pharmacogenomic screens reveals vulnerability in MPNSTs harboring loss of function mutations in the gene encoding products of the polycomb repressive complex 2 (PRC2)

    Prof Christopher L. Moertel, University of Minnesota School of Medicine, University of Minnesota Masonic Children's Hospital

    09:40

    Overall survival amongst patients with neurofibromatosis type 1 and malignant peripheral nerve sheath tumor

    Stine Bogetofte Thomasen, Research Student, Aarhus University Hospital, Denmark

    09:50

    Increased risk of endocrine morbidity in individuals with NF1: A Danish population-based cohort study

    Line Kenborg, Senior Scientist, Danish Cancer Society Research Center

    10:00

    Questions from Oral Presentations

    Questions from Oral Presentations

    10:10

    Keynote Lecture: Treatment of Ependymoma in NF2

    Prof Michel Kalamarides
    Professor and Director of Neurosurgery
    Pitie-Salpetrire Hospital
  • Prof Michel Kalamarides Professor and Director of Neurosurgery at Pitie-Salpetrire Hospital 
  • 10:40

    Radiation treatment of benign tumours in NF2-schwannomatosis: a national study of 266 irradiated patients showing a significant increase in malignancy

    Prof Gareth Evans
    Professor in Medical Genetics and Cancer Epidemiology Clinical Lead Manchester HSS NF2 Service
    University of Manchester UK
    Prof. Gareth Evans Professor in Medical genetics and Cancer Epidemiology, University of Manchester, UK

    10:50

    Challenges of a giant thoracic meningocele with insights from the histology

    Mr Joshi George, Consultant Neurosurgeon HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust and Northern Care Alliance NHS Foundation Trust

    11:00

    Keynote Lecture: Animal Models in NF

    Prof Marco Giovannini
    Professor of Neck and Head Surgery
    University of California Los Angeles

    Keynote Lecture: Animal Models in NF

    11:30

    Poster Presentations - Mezzanine floor - 11:30am - 13:00pm

    Poster Presentations - Mezzanine floor

    11:30

    Breakout sessions - 11:30am - 13:00pm

    • Breakout Session 1: Mental Health In NF Special Interest Group- Leads Dr Shruti Garg , Louise Robinson and Andre Reitman
    • Breakout session 2: Update on the International Neurofibromatosis and Schwannomatosis Genes Variant Curation Expert Panel (VCEP)” Prof Scott Plotkin and Dr. Elisabeth Castellanos Germans Trias & Pujol Research Institute (IGTP) and Coordinator of Clinical Genomics Unit at Clinical Laboratory of North Metropolitan (LCMN) located at Hospital University Germans Trias & Pujol.Badalona, Barcelona (Catalonia, Spain).

    12:00

    Lunch and Networking

    Lunch and Networking

    13:00

    Parallel sessions: Oral Presentations NF1/NF2

     

    NF1 - International Suite - Level 3

    Chairs:

    Professor Ros Ferner Professor of Neurology and National Lead Guy's and St Thomas' Foundation Trust and HSS Complex NF1 Service in the UK

    Dr John Ealing Consultant Neurologist  HSS Complex NF1 Service Manchester University NHS Foundation Trust and Northern Care Alliance NHS Trust

    NF2 - Senate Suite - Level 2

    Chairs: 

    Professor Andy King, Professor of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Manchester, Co-Director, Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Manchester, UK,

    Dr Claire Forde, Consultant Clinical Geneticist HSS NF2 service Manchester, Manchester University Hospital NHS Foundation Trust

    Comparison of a STIR- and T1-weighted-based radiomics model to differentiate between plexiform neurofibromas and malignant peripheral nerve sheath tumors in neurofibromatosis type 1

    Professor Scott Plotkin, Professor of Neurology, Harvard

    Multiple meningiomas as a criterion for the diagnosis of Neurofibromatosis Type 2 and other tumor predisposition syndromes

    Dr. Cathal Hannan, Neurosurgery ,Manchester Centre for Clinical Neurosciences

    Pregnancy and the risk for cancer among women with neurofibromatosis type 1

    Roope Kallionpää, Senior Researcher Institute of Biomedicine, University of Turku, Finland

    Antisense oligonucleotides targeting exon 11 are able to partially rescue the Neurofibromatosis Type 2 phenotype in vitro.

    Núria Catasús, Postdoctoral researcher, Germans Trias i Pujol Research Institute (IGTP)

    Synthetic lethal screening identifies existing autophagy drugs with selective viability effects on Neurofibromatosis type-1 model systems

    Megan Stevens,Post-doctoral researcher,The Living Systems Institute, University of Exeter, Exeter, UK

    Reprogram the tumor microenvironment to prevent tumor-induced hearing loss and augments treatment efficacy in NF2 schwannoma rodent models

    Dr. Lei Xu, Assistant Professor,Massachusetts General Hospital

    Unbalancing the Ras/MAPK pathway and the cAMP/PKA pathway as a therapeutic strategy for cutaneous neurofibromas

    Dr. Eduard Serra, Group Leader, Germans Trias i Pujol Research Institute (IGTP)

     

    Susceptibility locus for sporadic vestibular schwannoma identified by genome-wide association analysis

    Dr Miriam Smith,Senior Lecturer in Cancer Genomics, The University of Manchester

     

    Aberrant GABAergic neuronal development leads to disrupted contactin expression in a human induced pluripotent stem cell model of Neurofibromatosis 1-Autism

    Julieta O'Flaherty, PhD student, Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester

     

    The inflammatory and microvascular microenvironment in sporadic and neurofibromatosis type II related vestibular schwannoma (VS): a comparative imaging and pathology study 

    Daniel Lewis, University of Manchester 

    A case-only study in 1,333 neurofibromatosis type 1 patients to identify common genetic modifiers of cutaneous, subcutaneous, and plexiform neurofibromas

    Laurence Pacot, PhD student, PharmDAP-HP.Centre - Université Paris Cité

    "Immunogenic subtype" characterised by macrophages infiltration predominantly comprise meningiomas in neurofibromatosis type 2 patients

    Dr. Yu Teranishi , Assistant  Professor, The University of Tokyo Hospital, Department of Neurosurgery  

    14:00

    Questions from Parallel Sessions

    NF1 - Park Lane Suite - Level 4 NF2 - Park Avenue Suite - Level 4
    Questions  Questions

    14:15

    Networking and Coffee Break

    Networking and Coffee Break

    14:35

    Chairs - Dr Grace Vassallo and Professor John-Paul Kilday

    • Dr. Grace Vassallo- Consultant Paediatric Neurologist and Clinical Lead HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust.
    • Prof JP Kilday Consultant Paediatric Neurooncologist for the Complex NF1 service.

    14:35

    The ultimate in MDT work-Paediatric NF1 case.

    • Dr. Grace Vassallo- Consultant Paediatric Neurologist and Clinical Lead HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust.
    • Dr. Amish Chinoy Consultant Paediatric Endocrinologist and Prof Z Mughal Consultant Metabolic Bone Medicine Complex NF1 Manchester
    • Mr. A. Tambe Consultant Paediatric Spinal Surgeon for the Complex NF1 service Manchester
    • Prof JP Kilday Consultant Paediatric Neurooncologist for the Complex NF1 service.
    • Dr Vivien Tang Consultant Paediatric Radiologist HSS C HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust

    •  

    14:45

    Can Selumetinib delay the need for surgery in Neurofibromatosis Type 1 (NF1) with a Spinal Phenotype? - a multi-disciplinary approach

  • Dr Alexander Lee, Consultant Medical Oncologist, The Christie NHS Foundation Trust and HSS Complex NF1 Service Manchester University Hospital NHS Foundation Trust
  • 14:55

    Questions from Case Study

    Open questions from the Audience

    15:00

    Keynote Presentation: Medical Therapy in NF2

    Prof Scott Plotkin
    Professor of Neurobiology
    Harvard
    Keynote Lecture Medical Therapy in NF2

    15:30

    Symposium: Advancing treatments for NF1 related cognitive and behavioural difficulties

    Dr. Shruti Garg
    Consultant in Child and Adolescent Psychiatry and Clinical Research Fellow
    The Institute of Brain, Behaviour and Mental Health, University of Manchester, UK
    Symposium: Advancing treatments for NF1 related cognitive and behavioural difficulties Chair: Dr. Shruti Garg Consultant in Child and Adolescent Psychiatry, Royal Manchester Children’s Hospital and Clinical Senior Lecturer at University of Manchester Overview and introduction

    15:30

    Overview and Introduction

    Overview and Introduction

    15:40

    Insights from longitudinal studies of brain development in NF1 (EDEN study).

    Professor Emily Jones , Professor of Translational Neurodevelopment, Birkbeck College , London

    16:00

    Cortical oscillatory activity in NF1

    Samantha Booth, PhD Student University of Manchester

    16:20

    Early intervention studies in infancy

    Prof Jonathan Green, Professor of Child/Adolescent Psychiatry University of Manchester and Honorary Consultant Child & Adolescent Psychiatrist at Manchester University NHS Trust

    16:40

    Novel interventions in NF1

    Dr Shruti Garg, Garg Consultant in Child and Adolescent Psychiatry, Royal Manchester Children’s Hospital and Clinical Senior Lecturer at University of Manchester

    17:00

    Closing Address

    Prof Gareth Evans
    Professor in Medical Genetics and Cancer Epidemiology Clinical Lead Manchester HSS NF2 Service
    University of Manchester UK
    Dr Grace Vassallo
    Consultant Paediatric Neurologist and Clinical Lead HSS Complex NF1 Service
    Manchester University NHS Foundation Trust

    Closing Address Prof Evans and Dr. G.Vassallo

    17:30

    Close of Event

    Close of Event

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